John Lennon's 1964 Gibson J 160E acoustic guitar used during the recording of "Give Peace A Chance" and during John & Yoko's bed-in has quite the history before John drew the caricatures of him and Yoko on it to commemorate the Amsterdam and Montreal Bed-Ins.
The guitar started off as an original Sunburst 1964 Gibson J-160E (below). Serial #64309.
Then in 1967, John commissioned artists Simon and Marijke Posthuma, a.k.a. The Fool to give the guitar a psychedelic paint job for the "All You Need Is Love" satellite broadcast.
He later had the paint job professionally stripped and replaced the pickguard. This last time the guitar was seen in action was during the Bed-Ins for peace when he drew the two caricatures onto the guitar. Recently the guitar was put on display at the Rock and Roll Hall of Fame, on loan from the Lennon Estate.